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Complex Clinical Questions Databases

The Center for Knowledge Management (CKM) has a long history of providing comprehensive evidentiary support from vetted authoritative sources for both clinical and research queries at Vanderbilt Health. To capture the expertise, time, and effort that information scientists apply to evidence provision in response to complex questions and allow for knowledge reuse across the enterprise, CKM maintains multiple web-based repositories offering ongoing access to completed evidence packets. 

Responses to complex questions, or filtered evidence packets, contain: 

  • synthesis and summary of:
    • the primary and grey literature representing all current and relevant viewpoints on a topic;
    • when relevant, evidence and information from all applicable databases and resources pertaining to a specific genetic and/or protein variant.
  • select, filtered references with links to full-text articles;
  • expertly-formulated search statements linked to databases such as PubMed and Web of Science, to enable dynamic updates on the topic.

Complex question databases are searchable by keywords and/or browsable by topic and hospital unit from which the question originated.  Packets are viewable in html format and printable in pdf format. 

Evidence databases are available on the Vanderbilt Health network to the Vanderbilt Health community for reuse and future consultation. 

Evidence-Based Site – evidence packets addressing complex, inpatient-specific clinical questions received on rounds or via the electronic health record system

Diagnostic Management Teams (DMT) - evidence packets informing the interpretation of genetic and complex laboratory evaluations for Vanderbilt Health Diagnostic Management Teams

Genetic Research Questions Archive - filtered evidence packets addressing biochemical, genetic, protein, and structural questions

Outpatient Clinical Informatics Consult Database - evidence packets addressing complex, patient-specific clinical questions received from Vanderbilt Health ambulatory care physicians

Publications/Presentations

  • “Analysis of Clinical Informatics Literature Module,” Introduction to Clinical Informatics (ACI 6110) course, Masters of Science in Applied Clinical Informatics (MSACI) program, Vanderbilt University, Department of Biomedical Informatics. Fall 2016 - present.

  • Koonce TY, Giuse DA, Blasingame MN, Su J, William AM, Biggerstaff PL, Osterman TJ, Giuse NB. The personalization of evidence: using intelligent datasets to inform the process. American Medical Informatics Fall Symposium [virtual], November 2020.

  • "Information Retrieval and Assessing Evidence Module,” Clinical Decision Support and Evidence-based Patient Care (ACI 6120) course, Masters of Science in Applied Clinical Informatics (MSACI) program, Vanderbilt University, Department of Biomedical Informatics. Spring 2017.